{"id":1152,"date":"2020-11-20T15:00:05","date_gmt":"2020-11-20T18:00:05","guid":{"rendered":"http:\/\/pressreleases.scielo.org\/en\/?p=1152"},"modified":"2023-03-29T14:09:24","modified_gmt":"2023-03-29T17:09:24","slug":"antifungal-action-of-liriodenine-in-systemic-mycoses","status":"publish","type":"post","link":"https:\/\/pressreleases.scielo.org\/en\/2020\/11\/20\/antifungal-action-of-liriodenine-in-systemic-mycoses\/","title":{"rendered":"Antifungal action of liriodenine in systemic mycoses"},"content":{"rendered":"

Adriele Dandara Levorato Vinche, PhD Researcher, Department of Tropical Disease and Imaging Diagnosis, Botucatu Medical School, S\u00e3o Paulo State University (UNESP), Botucatu, SP, Brazil.<\/strong><\/p>\n

\"\"<\/a>Over the past few years, there has been a growth in fungal infections and resistance to antifungals available on the market. Thus, the discovery and development of new drugs are extremely important. The article \u201cAntifungal activity of liriodenine on agents of systemic mycoses, with emphasis on the genus Paracoccidioides<\/em><\/a>\u201d, published in the Journal of Venomous Animals and Toxins including Tropical Diseases<\/em> (vol. 26), presents the antifungal activity of liriodenine on several types of fungi that cause systemic mycoses. Liriodenine is an alkaloid extracted from plants that possesses antibacterial, antiparasitic and cytotoxic properties.<\/p>\n

The study was carried out by Adriele Dandara Levorato Vinche during her PhD research and was conducted from March 2014 to December 2017 at Botucatu Medical School, S\u00e3o Paulo State University (UNESP), under the supervision of Rinaldo Poncio Mendes, head professor of the Department of Tropical Disease and Imaging Diagnosis. Researchers from the Institute of Biosciences of Botucatu, UNESP, and the Universidad de Ciencia y Artes de Chiapas, Mexico, participated in the research, carrying out the extraction and identification of liriodenine.<\/p>\n

\"\"<\/a><\/p>\n

The antifungal activity was evaluated by the liriodenine sensitivity test, using different strains of fungi. The test revealed that liriodenine has an antifungal effect on most of the strains evaluated, inhibiting the growth of microorganisms. Electron microscopy demonstrated that the alkaloid has a fungicidal effect, that is, it induces the death of the microorganism.<\/p>\n

The results indicate that liriodenine is a promising antifungal compound. However, further studies are required in animal models in order to evaluate the efficacy and safety of this compound. After that, the possibility of treating human infections must be evaluated.<\/p>\n

To read the article, acess<\/h3>\n

VINCHE, A. D. L. et al.\u00a0<\/em>Antifungal activity of liriodenine on agents of systemic mycoses, with emphasis on the genus Paracoccidioides.\u00a0J. Venom. Anim. <\/em>Toxins incl. Trop. Dis<\/em>\u00a0[online]. 2020, vol.26 [viewed 20 November 2020] http:\/\/dx.doi.org\/10.1590\/1678-9199-jvatitd-2020-0023<\/a><\/u>. Available from: http:\/\/ref.scielo.org\/67fd8n<\/a>.<\/p>\n

External links<\/h3>\n

Facebook \u2013 Journal of Venomous Animals and Toxins including Tropical Diseases: https:\/\/www.facebook.com\/JVATiTD<\/a><\/p>\n

Journal of Venomous Animals and Toxins including Tropical Diseases: http:\/\/www.jvat.org\/<\/a><\/p>\n

Journal of Venomous Animals and Toxins including Tropical Diseases \u2013 JVATITD: http:\/\/www.scielo.br\/jvatitd<\/a><\/p>\n

Twitter \u2013 Journal of Venomous Animals and Toxins including Tropical Diseases: https:\/\/twitter.com\/JVATiTD<\/a><\/p>\n

Curr\u00edculo Lattes \u2013 Adriele Dandara Levorato Vinche: http:\/\/lattes.cnpq.br\/6363090645820406<\/a><\/p>\n

Faculdade de Medicina de Botucatu FMB\/Unesp: https:\/\/www.fmb.unesp.br\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The discovery and development of new compounds with antifungal action are essential to fight the emergence of resistant microorganisms. Liriodenine, a molecule extracted from plants, has shown to act against several strains of fungi that cause systemic mycoses. …<\/span> Read More →<\/span><\/a><\/span><\/p>\n","protected":false},"author":463,"featured_media":1161,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[120,12],"tags":[121,206],"class_list":["post-1152","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jvatitd","category-press-releases","tag-journal-of-venomous-animals-and-toxins-including-tropical-diseases","tag-veterinary-medicine"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/users\/463"}],"replies":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/comments?post=1152"}],"version-history":[{"count":4,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1152\/revisions"}],"predecessor-version":[{"id":1162,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1152\/revisions\/1162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/media\/1161"}],"wp:attachment":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/media?parent=1152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/categories?post=1152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/tags?post=1152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}