{"id":1614,"date":"2022-06-03T10:00:02","date_gmt":"2022-06-03T13:00:02","guid":{"rendered":"http:\/\/pressreleases.scielo.org\/en\/?p=1614"},"modified":"2023-03-28T13:06:07","modified_gmt":"2023-03-28T16:06:07","slug":"expanding-the-horizons-of-medical-science-in-fighting-portal-hypertension-with-mini-pigs","status":"publish","type":"post","link":"https:\/\/pressreleases.scielo.org\/en\/2022\/06\/03\/expanding-the-horizons-of-medical-science-in-fighting-portal-hypertension-with-mini-pigs\/","title":{"rendered":"Expanding the horizons of medical science in fighting portal hypertension with mini pigs"},"content":{"rendered":"

Rosa Emilia Moraes, Scientific journalist at Linceu Editorial, S\u00e3o Jos\u00e9 dos Campos, SP, Brasil.<\/strong><\/p>\n

\"Logo<\/a>Experimental surgeries in animal models are essential for the development and refinement of medical procedures that aim to cure diseases, save lives and improve the conditions of patients who need these interventions, as in the case of hepatectomy for the treatment of liver metastasis, reducing mortality from multiple failure of the organ.<\/p>\n

Portal hypertension is a health problem that can lead to serious complications, including death from hemorrhagic shock due to rupture of esophagogastric varices. The high incidence and mortality rates of frontal hypertension in patients admitted with upper gastrointestinal bleeding at the Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), where the study was carried out, justify this unprecedented study developed by researchers from S\u00e3o Paulo and Rio de Janeiro, in southeastern Brazil.<\/p>\n

The article Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study<\/a>, published by ACTA Cir\u00fargica Brasileira (v.37 ed 1, 2022) , sought to validate an unprecedented experimental model in br1 mini pigs, using the partial portal vein ligation technique to induce portal hypertension and esophageal varices described by Jensen et. al. in the 80s.<\/p>\n

\"\"

Image: author.<\/em><\/p><\/div>\n

Figure 1. Ligadura calibrada da veia porta.<\/strong><\/p>\n

In their study, the researchers observed that the technique \u2013 already tested in small to medium-sized animals, from rodents to dogs \u2013 is undoubtedly effective in producing portal hypertension, but the formation of esophagogastric varices was not observed in all species. Noting that these different results could be related to differences in the portal system of each species, the authors proposed this experiment with five specimens of br1 mini pigs. The portal systems of humans and pigs are similar at a morphological and microstructural level. The minipig has splenic hemodynamics and hepatic metabolism like humans, providing more accurate results.<\/p>\n

After a clear and detailed description of the technical procedure to which the models were submitted \u2013 including the compliance of these actions with the current legislation on ethics in animal research \u2013 the authors concluded that the animal model obtained is valid for the production of portal hypertension in mini pigs br1, but not in the formation of esophageal varices. Thus, the study suggests a starting point for the development of research in this field with medium-sized animals and indicates the direction to follow in future experiments to obtain a reproducible and reliable model.<\/p>\n

\"A

Image: author.<\/em><\/p><\/div>\n

Figure 2. Animal de experimenta\u00e7\u00e3o (minipig BR-1)<\/strong><\/p>\n

Read more<\/h3>\n

JENSEN, L.S., et al<\/em>. Effect of acute portal hypertension on hepatosplanchnic hemodynamics and liver function. Scandinavian Journal of Gastroenterology<\/em> [online]. 1986, vol. 21, no. 5, pp. 568 to 572 [viewed 2 June 2022]. https:\/\/doi.org\/10.3109\/00365528609003101<\/a>. Available from: https:\/\/www.tandfonline.com\/doi\/abs\/10.3109\/00365528609003101<\/a><\/p>\n

MARIANO, M. Miniature swine (minipig) in biomedical experimental research: the Minipig br1. Acta Cir\u00fargica Brasileira<\/em> [online]. 2003, vol. 18, no. 5, pp. 387-391. https:\/\/doi.org\/10.1590\/S0102-86502003000500003<\/a>. Available from: https:\/\/www.scielo.br\/j\/acb\/a\/Cb7wfGp9MDhYgsxdXVgMLdm\/<\/a><\/p>\n

To read the article, access<\/h3>\n

MALUF FILHO, F., et al<\/em>. Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study. Acta Cir\u00fargica Brasileira<\/em> [online]. 2022, vol. 37, no. 1, e370103 [viewed 2 June 2022]. https:\/\/doi.org\/10.1590\/acb370103<\/a>. Available from: https:\/\/www.scielo.br\/j\/acb\/a\/X6QbxS4gCX6ttD3sXPkh68w\/<\/a><\/p>\n

Link(s)<\/h3>\n

Laborat\u00f3rios de Investiga\u00e7\u00e3o M\u00e9dica- LIM\/HCFMUSP : https:\/\/limhc.fm.usp.br\/portal\/<\/a><\/p>\n

MINIPIG Pesquisa e Desenvolvimento LTDA : http:\/\/www.minipig.com.br\/minipig.asp<\/a><\/p>\n

Acta Cir\u00fargica Brasileira \u2013 ACB: https:\/\/www.scielo.br\/j\/acb\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

In search of new alternatives for the treatment of portal hypertension, a model validation in medium-sized animals was performed, allowing the improvement of techniques applied in cases of gastrointestinal hemorrhage and indicating the direction for advances in diagnostic and therapeutic procedures that aim to cure diseases and save lives. …<\/span> Read More →<\/span><\/a><\/span><\/p>\n","protected":false},"author":606,"featured_media":1615,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[171,8,12],"tags":[172,191],"class_list":["post-1614","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-acb","category-health-sciences","category-press-releases","tag-acta-cirurgica-brasileira","tag-medicine"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/users\/606"}],"replies":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/comments?post=1614"}],"version-history":[{"count":3,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1614\/revisions"}],"predecessor-version":[{"id":1982,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1614\/revisions\/1982"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/media\/1615"}],"wp:attachment":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/media?parent=1614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/categories?post=1614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/tags?post=1614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}