{"id":1679,"date":"2022-06-10T14:00:33","date_gmt":"2022-06-10T17:00:33","guid":{"rendered":"http:\/\/pressreleases.scielo.org\/en\/?p=1679"},"modified":"2024-05-06T08:33:24","modified_gmt":"2024-05-06T11:33:24","slug":"cevap-ready-for-the-21st-century","status":"publish","type":"post","link":"https:\/\/pressreleases.scielo.org\/en\/2022\/06\/10\/cevap-ready-for-the-21st-century\/","title":{"rendered":"CEVAP: ready for the 21st century"},"content":{"rendered":"

Rui Seabra Ferreira J\u00fanior, Executive Director, Center for the Study of Venoms and Venomous Animals (CEVAP),\u00a0S\u00e3o Paulo State University (UNESP), Botucatu, SP, Brazil.<\/strong><\/p>\n

\"JournalIn 2023, CEVAP will celebrate 30 years of existence. Almost three decades have passed since its establishment. During this period, a lot of effort, commitment and dedication were necessary for the Center to develop solid foundations for its sustainability. The group of researchers, specialized in the use of animal venoms and toxins as a study tool, since the beginning of the creation of CEVAP has worked tirelessly for its expansion in the 21st <\/sup>century.<\/p>\n

To speed up the dissemination of scientific discoveries, in 1995 the researchers launched the first electronic scientific journal in Brazil, the Journal of Venomous Animals and Toxins including Tropical Diseases<\/em> (www.jvat.org). JVATiTD<\/em>, the official publication of CEVAP, currently has a worldwide impact and ranks among the leading journals on tropical diseases and toxinology. It should be noted that the same commitment that led CEVAP professionals to mature as researchers also led them to improve their skills as editors. Thus, knowing more and more about the work practices of experienced international editors and publishers, they were able to bring new insights to the journal, which directly reflected on the growth of its metrics.<\/p>\n

CEVAP, as a unit of translational science of UNESP, in addition to working in research and scientific dissemination through its journal, also offers university extension programs, specialization in diagnostic and therapeutic innovation, and graduate studies in clinical research. Investing in innovation and entrepreneurship, the CEVAP group has developed and produced two biopharmaceuticals in the last decades. Based on well-founded basic studies, it was possible to choose candidate molecules that generated, respectively, the Heterologous Fibrin Sealant and the Apilic Antivenom.<\/p>\n

\"\"

Image: CEVAP\/UNESP.<\/em><\/p><\/div>\n

Figure 1. The future of CEVAP. Proposed model for the fa\u00e7ade of the Factory for the Production of Pilot Batches for Clinical Research.<\/strong><\/p>\n

JVATiTD<\/em> carries in its DNA part of the history of the development of these two bioproducts, since peer-reviewed articles on Fibrin Sealant began to be published in the journal in the late 1990s. These articles contain the entire history of the process from the initial experimental tests, election of laboratory techniques in compliance with current regulatory standards, identification of donor animals of candidate molecules, up to the improvement and application of products in humans1-21<\/sup>. In the same way, the journal subsequently followed the publications related to the Apilic Antivenom, a bioproduct developed in the last decade22<\/sup>.<\/p>\n

Following this groundbreaking path, after the discovery and patenting of these two biopharmaceuticals, CEVAP took part in phase I\/II clinical trials to prove their safety and possible clinical efficacy. Due to the promising results published in scientific journals with a high impact factor, including JVATiTD<\/em>, CEVAP researchers sought funding for the construction of the Factory for the Production of Pilot Batches for Clinical Research \u2013 the first with this profile in America Latina \u2013 for the production of biopharmaceutical samples for clinical trials23<\/sup>.<\/p>\n

This factory will act as a Contract Development and Manufacturing Organization with Good Manufacturing Practices (GMP-CDMO) capable of working on the development of a drug from its preformulation, laboratory-scale production, scalability for industrial production and carrying out biological, preclinical and clinical tests \u2013 tasks that Contract Research Organizations (CROs) are able to perform within good production practices.<\/p>\n

In this way, CEVAP prepares itself to support multiple process modalities and workflows relative to antibody, vaccine, cell and gene therapies, contributing to the development of technologies, promoting improvement of health in Brazil, in addition to generating wealth for the country. In this context, JVATiTD<\/em> intends to follow in the footsteps of its institution, seeking innovation and quality so that on its 30th anniversary it can also celebrate the positive results that will guarantee its permanence in the competitive world of scientific publishing.<\/p>\n

Read more<\/h3>\n
    \n
  1. SARTORI FILHO, R, et al<\/em>. Use of fibrin glue derived from snake venom in testicular biopsy of rams. Journal of Venomous Animals and Toxins<\/em> [online]. 1998, vol. 4, no. 1, pp. 23-35 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S0104-79301998000100003<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvat\/a\/VtXMqQqm3BPJnYCwLJHfrWd\/<\/a><\/li>\n
  2. THOMAZINI-SANTOS, I.A., et al<\/em>. The evaluation of clotting time in bovine thrombin, Reptilase\u00ae, and thrombin-like fraction of Crotalus durissus terrificus<\/em> venom using bovine, equine, ovine bubaline and human crioprecipitates. Journal of Venomous Animals and Toxins<\/em> [online]. 1998, vol. 4, no. 2, pp. 120-136 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S0104-79301998000200004<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvat\/a\/sPpY3SRdLSwCNVqbKM4k7nw\/<\/a><\/li>\n
  3. LEITE, C.V.S., et al<\/em>. An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom. Journal of Venomous Animals and Toxins<\/em> [online]. 2000, vol. 6, no. 2, pp. 180-93 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S0104-79302000000200004<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvat\/a\/KzWkpRNwQ5Nx49ByyKLXbCF\/<\/a><\/li>\n
  4. CHALHOUB, M., et al<\/em>. The use of snake venom derived fibrin glue in hysterorrhaphy of ovine caesarean surgery. Journal of Venomous Animals and Toxins<\/em> [online]. 2000, vol. 6, no. 2, pp. 220-237 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S0104-79302000000200007<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvat\/a\/4P3sBJ7ZSp37qFQXD3KfT9L\/<\/a><\/li>\n
  5. THOMAZINI-SANTOS, I.A., et al<\/em>. Surgical adhesives. Journal of Venomous Animals and Toxins<\/em> [online]. 2001, vol. 7, no. 2, pp. 159-171 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S0104-79302001000200002<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvat\/a\/fBxh9swpmPZrQVvS6xWJvGd\/<\/a><\/li>\n
  6. MORAES, J.R.E., et al<\/em>. Experimental use of fibrin glue derived from snake venom in non-pregnant canine uterus. Journal of Venomous Animals and Toxins<\/em> [online]. 2004, vol. 10, no. 2, pp. 133-43 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S1678-91992004000200003<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/yc7MFxVQVNq6CF8qVB3Pn7s\/<\/a><\/li>\n
  7. RAHAL, S.C., et al<\/em>. Effect of fibrin glue derived from snake venom on the viability of autogenous split-thickness skin graft. Journal of Venomous Animals and Toxins<\/em> [online]. 2004, vol. 10, no. 2, pp. 161-172 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S1678-91992004000200006<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/Xjck5mMNwmRxBy3YsxKzp4B\/<\/a><\/li>\n
  8. FERRARO, G.C., et al<\/em>. Clinical and morphological evaluation of snake venom derived fibrin glue on the tendon healing in dogs. Journal of Venomous Animals and Toxins<\/em> [online]. 2005, vol. 11, no. 4, pp. 433-446 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S1678-91992005000400005<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/3Rzdkd4RjZnvqJYnm4WWngm\/<\/a><\/li>\n
  9. FERRARO, G.C., et al<\/em> Effect of snake venom derived fibrin glue on the tendon healing in dogs: clinical and biomechanical study. Journal of Venomous Animals and Toxins<\/em> [online]. 2005, vol. 11, pp. 3, pp. 261-74 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S1678-91992005000300005<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/PcWgwyXmpdGTLfhKNTV6fCp\/<\/a><\/li>\n
  10. SAMPAIO, R.L., et al<\/em>. Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers: experimental study in dogs (Canis familiaris<\/em>, Linnaeus, 1758). Journal of Venomous Animals and Toxins<\/em> [online]. 2007, vol. 13, no. 4, pp. 857-873 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S1678-91992007000400014<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/V4sq6SJsjy6HsNjpVbmQ57m\/<\/a><\/li>\n
  11. GATTI, M.A.N., et al<\/em>. Treatment of venous ulcers with fibrin sealant derived from snake venom. Journal of Venomous Animals and Toxins<\/em> [online]. 2011, vol. 17, no. 2, pp. 226-229 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/S1678-91992011000200015<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/qLtYtwZR9bcqwQSrWcr9wpJ\/<\/a><\/li>\n
  12. FERREIRA J\u00daNIOR, R.S.F. Autologous or heterologous fibrin sealant scaffold: which is the better choice? Journal of Venomous Animals and Toxins<\/em> [online]. 2014, vol. 20, no. 1, pp. 31 [viewed 9 June 2022]. https:\/\/doi.org\/10.1186\/1678-9199-20-31<\/a>. Available from: https:\/\/jvat.biomedcentral.com\/articles\/10.1186\/1678-9199-20-31<\/a><\/li>\n
  13. BISCOLA, N.P., et al<\/em>. Multiple uses of fibrin sealant for nervous system treatment following injury and disease. Journal of Venomous Animals and Toxins<\/em> [online]. 2017, vol. 23, no. 1, 13 [viewed 9 June 2022]. https:\/\/doi.org\/10.1186\/s40409-017-0103-1<\/a>. Available from: https:\/\/jvat.biomedcentral.com\/articles\/10.1186\/s40409-017-0103-1<\/a><\/li>\n
  14. FERREIRA JUNIOR, R.S., et al<\/em>. Heterologous fibrin sealant derived from snake venom: from bench to bedside \u2013 an overview. Journal of Venomous Animals and Toxins<\/em> [online]. 2017, vol. 23, no. 1, 21 [viewed 9 June 2022]. https:\/\/doi.org\/10.1186\/s40409-017-0109-8<\/a>. Available from: https:\/\/jvat.biomedcentral.com\/articles\/10.1186\/s40409-017-0109-8<\/a><\/li>\n
  15. MOZAFARI, R., et al<\/em>. Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair. Journal of Venomous Animals and Toxins<\/em> [online]. 2018, vol. 24, no. 1, 11 [viewed 9 June 2022]. https:\/\/doi.org\/10.1186\/s40409-018-0147-x<\/a>. Available from: https:\/\/jvat.biomedcentral.com\/articles\/10.1186\/s40409-018-0147-x<\/a><\/li>\n
  16. BUCHAIM, D.V., et al<\/em>. Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review Journal of Venomous Animals and Toxins<\/em> [online]. 2019, vol. 25, e20190038 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/1678-9199-JVATITD-2019-0038<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/HDLmtVrKNs3mHFrHx8tB6kL\/<\/a><\/li>\n
  17. CASSARO, C.V., et al<\/em>. Fibrin biopolymer as scaffold candidate to treat bone defects in rats. Journal of Venomous Animals and Toxins<\/em> [online]. 2019, vol. 25, e20190027 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/1678-9199-JVATITD-2019-0027<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/bBz3gt5rvshCxz9CtfcrTRn\/<\/a><\/li>\n
  18. ABBADE, L.P.F., et al<\/em>. Chronic venous ulcers: a review on treatment with fibrin sealant and prognostic advances using proteomic strategies. Journal of Venomous Animals and Toxins<\/em> [online]. 2020, vol. 26, e20190101 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/1678-9199-JVATITD-2019-0101<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/NdNG8sKf9ddRtdvbsp3VSrR\/<\/a><\/li>\n
  19. KEMPE, P.R.G., et al<\/em>. Neuroprotection and immunomodulation by dimethyl fumarate and a heterologous fibrin biopolymer after ventral root avulsion and reimplantation. Journal of Venomous Animals and Toxins<\/em> [online]. 2020, vol. 26, e20190093 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/1678-9199-JVATITD-2019-0093<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/DqDqx49mcRTTpm8shXgHhLg\/<\/a><\/li>\n
  20. PONTES, L.G., et al<\/em>. Extracellular vesicles in infectious diseases caused by protozoan parasites in buffaloes. Journal of Venomous Animals and Toxins<\/em> [online]. 2020, vol. 26, e20190067 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/1678-9199-JVATITD-2019-0067<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/XdcrDBMqdGLzWrRVdHBBp7w\/<\/a><\/li>\n
  21. BUCHAIM, D.V., et al<\/em>. A biocomplex to repair experimental critical size defects associated with photobiomodulation therapy. Journal of Venomous Animals and Toxins<\/em> [online]. 2022, vol. 28, e20210056 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/1678-9199-JVATITD-2021-0056<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/yzKTwtLSyxhxhJb4xwtP5yP\/<\/a><\/li>\n
  22. BARBOSA, A.N., et al<\/em>. A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera<\/em>) attack with a new apilic antivenom Journal of Venomous Animals and Toxins<\/em> [online]. 2017, vol. 23, 14 [viewed 9 June 2022]. doi: 10.1186\/s40409-017-0106-y. Available from: https:\/\/jvat.biomedcentral.com\/articles\/10.1186\/s40409-017-0106-y<\/a><\/li>\n
  23. FERREIRA JUNIOR, R.S., et al<\/em>. Launching a CDMO in Brazil aiming to develop biopharmaceuticals for clinical trials Journal of Venomous Animals and Toxins<\/em> [online]. 2022, vol. 28, e20220017 [viewed 9 June 2022]. https:\/\/doi.org\/10.1590\/1678-9199-JVATITD-2022-0017<\/a>. Available from: https:\/\/www.scielo.br\/j\/jvatitd\/a\/bR7KGg6xkj6wTmhgcXGx4NH\/<\/a><\/li>\n<\/ol>\n

    Link(s)<\/h3>\n

    CEVAP\/UNESP – Social media: Facebook<\/a> | Twitter<\/a><\/p>\n

    CEVAP\/UNESP | Institutional video | 2020<\/a><\/p>\n

    CEVAP\/UNESP | Signing Ceremony | Manufacturing Plant for Production of Clinical Research Samples<\/a><\/p>\n

    JVATITD – Social Media: Facebook<\/a> | Twitter<\/a><\/p>\n

    Journal of Venomous Animals and Toxins including Tropical Diseases: https:\/\/www.jvat.org\/<\/a><\/p>\n

    Journal of Venomous Animals and Toxins including Tropical Diseases \u2013 JVATITD: https:\/\/www.scielo.br\/j\/jvatitd\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    CEVAP has been working diligently since its founding in translational research with animal venoms. During this 30-year journey, a scientific journal was launched, two biopharmaceuticals were developed and numerous professionals, academic or not, were trained. Now, CEVAP is heading towards its future looking towards the creation of a factory aiming at scientific research. …<\/span> Read More →<\/span><\/a><\/span><\/p>\n","protected":false},"author":624,"featured_media":1680,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3,5,8,120,177,12,164],"tags":[121,206],"class_list":["post-1679","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agricultural-sciences","category-biological-sciences","category-health-sciences","category-jvatitd","category-jvatitd-week","category-press-releases","category-special-weeks","tag-journal-of-venomous-animals-and-toxins-including-tropical-diseases","tag-veterinary-medicine"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1679","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/users\/624"}],"replies":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/comments?post=1679"}],"version-history":[{"count":5,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1679\/revisions"}],"predecessor-version":[{"id":2296,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1679\/revisions\/2296"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/media\/1680"}],"wp:attachment":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/media?parent=1679"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/categories?post=1679"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/tags?post=1679"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}