{"id":1685,"date":"2022-06-20T14:00:24","date_gmt":"2022-06-20T17:00:24","guid":{"rendered":"http:\/\/pressreleases.scielo.org\/en\/?p=1685"},"modified":"2023-03-28T13:38:08","modified_gmt":"2023-03-28T16:38:08","slug":"genomic-monitoring-of-holstein-cattle-as-a-strategy-in-dairy-production","status":"publish","type":"post","link":"https:\/\/pressreleases.scielo.org\/en\/2022\/06\/20\/genomic-monitoring-of-holstein-cattle-as-a-strategy-in-dairy-production\/","title":{"rendered":"Genomic monitoring of Holstein cattle as a strategy in dairy production"},"content":{"rendered":"

Maria Luiza De Grandi, journalist of Ci\u00eancia Rural, Santa Maria, Rio Grande do Sul, Brazil.<\/strong><\/p>\n

Carolina Briano-Rodriguez, Division de Laborat\u00f3rios Veterin\u00e1rios Miguel C. Rubino- Laborat\u00f3rio Regional Este Treinta y Tres<\/em> (MGAP), Treinta y Tres, Uruguay.<\/strong><\/p>\n

\"\"<\/a><\/p>\n

The Holstein Friesian bull breed, popularly known as Holstein, of North American origin, is widely used around the world, mainly for milk production. In Uruguay, dairy production based on the Holstein breed is one of the most important sectors of the country’s economy, but genetic disorders in Holstein cattle have been a problem, compromising the sustainability of milk production (RODR\u00cdGUEZ -MART\u00cdNEZ et al<\/em>., 2008; KELLY, L., et al<\/em>. 2012).<\/p>\n

Researchers from the Division de Laborat\u00f3rios Veterin\u00e1rios Miguel C. Rubino<\/em> (MGAP), in partnership with the Faculdade de Veterin\u00e1ria da Rep\u00fablica<\/em> (UDELAR) and the Instituto Nacional de Investigaci\u00f3n Agropecu\u00e1ria<\/em> (INIA) developed the article Lethal and semi-lethal mutations in holstein calves in Uruguay<\/a>, published in the journal Ci\u00eancia Rural<\/em> (vol. 51, no. 7). The objective of this research was to investigate the presence and spread of lethal and semi-lethal alleles causing embryonic death, abortions, fetal malformations and neonatal diseases in Holstein calves.<\/p>\n

To achieve the objective, the researchers used the GeneSeek customized Genomic Profiler -GGP- Bovine 50K BeadChip on 383 Holstein calves, between one and thirty days old, from 27 farms located in the main dairy regions of Uruguay. These blood samples were obtained in 2016 as part of a larger-scale epidemiological study (SCHILD et al., 2020). GeneSeek’s technology utilizes Illumina Infinium chemistry, with approximately 50,000 unique nucleotides assayed per sample. \u201cThis study demonstrates for the first time the presence of nine different lethal and semi-lethal mutations in the Holstein-Friesian breed in Uruguay\u201d, explains scientist Carolina Briano-Rodriguez.<\/p>\n

The survey results showed a high prevalence of carriers (85%) and calves (21%), including one or more of the following lethal alleles: Bovine Leukocyte Adhesion Deficiency (BLAD) (4); complex vertebral malformation (8); brachispine (13); cholesterol deficiency (10); syndactyly (16); Dutch haplotypes HH1 (17), HH3 (12), HH4 (4) and HH5 (1), most of which had never been previously reported in Uruguay.<\/p>\n

The research, developed in Uruguay, draws attention to hereditary diseases. \u201cThese diseases should be studied, including as differential diagnoses\/causes of embryonic loss or fetal mortality, stillbirths and malformed or immunosuppressed calves\u201d, highlights Carolina. \u201cThe diagnosis allows the implementation of tools such as directed mating, elimination of low-value animals, etc., which minimize prenatal losses, estimated at more than 6,000 pregnancies\/year in Uruguay\u201d. Innovative in its field, the research reiterates the importance of genomic monitoring of animals. \u201cGenomic monitoring of carrier animals is necessary to prevent the spread of lethal and semi-lethal alleles in the Holstein cattle population, determine their impact on dairy cattle fertility and reduce economic losses to dairy farming\u201d, concludes the scientist.<\/p>\n

References<\/h3>\n

KELLY, L., et al<\/em>. Diagn\u00f3stico molecular de enfermedades hereditarias bovinas en el Uruguay. Veterinaria (Montevideo)<\/em>. 2012, vol.48, no.188, pp. 3-11 [viewed 20 June 2022]. Available from: http:\/\/www.revistasmvu.com.uy\/index.php\/smvu\/article\/view\/208<\/a><\/p>\n

RODRIGUEZ-MARTINEZ, H., et al<\/em>. Reproductive performance in high-producing dairy cows: can we sustain it under current practice. IVIS Reviews in veterinary Medicine<\/em>. 2008, vol. 1, no. 108, pp. 1-23 [viewed 20 June 2022]. Available from: http:\/\/urn.kb.se\/resolve?urn=urn:nbn:se:slu:epsilon-1-164<\/a><\/p>\n

To read the article, access<\/h3>\n

BRIANO-RODRIGUEZ, C., et al<\/em>. Lethal and semi-lethal mutations in Holstein calves in Uruguay. Cienc. Rural<\/em> [online]. 2021, vol. 51, no. 7, e20200734 [viewed 20 June 2022]. https:\/\/doi.org\/10.1590\/0103-8478cr20200734<\/a>. Available from: https:\/\/www.scielo.br\/j\/cr\/a\/vfbVrVnm8ScGgggSfpYNzSb<\/a><\/p>\n

External links<\/h3>\n

Ci\u00eancia Rural \u2013 Social media: Twitter<\/a>\u00a0|\u00a0Instagram<\/a>\u00a0|\u00a0Facebook<\/a><\/p>\n

Ci\u00eancia Rural:\u00a0http:\/\/coral.ufsm.br\/ccr\/cienciarural\/<\/a><\/p>\n

Ci\u00eancia Rural \u2013 CR:\u00a0https:\/\/www.scielo.br\/j\/cr\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Dairy production is one of the most important sectors of the Uruguayan economy. The genetic disorders of the \u201cHolstein\u201d breed cause production problems, compromising the sustainability of the milk production. The genomic monitoring of carrier animals is necessary to avoid the spread of lethal and semi-lethal alleles and to reduce the economic losses to dairy farming. …<\/span> Read More →<\/span><\/a><\/span><\/p>\n","protected":false},"author":106,"featured_media":1690,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3,20,12],"tags":[192,21],"class_list":["post-1685","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agricultural-sciences","category-cr","category-press-releases","tag-agronomy","tag-ciencia-rural"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/users\/106"}],"replies":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/comments?post=1685"}],"version-history":[{"count":5,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1685\/revisions"}],"predecessor-version":[{"id":1692,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/posts\/1685\/revisions\/1692"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/media\/1690"}],"wp:attachment":[{"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/media?parent=1685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/categories?post=1685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pressreleases.scielo.org\/en\/wp-json\/wp\/v2\/tags?post=1685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}