Author: Daniela Barros

Predictive factors for permanent congenital hypothyroidism was shown by a real-life study in Brazil

Photo: A doctor is holding a baby on an office table. She is smiling and looking at the baby. Baby looks at the camera and seems to bite a finger.

Congenital hypothyroidism can be permanent (PCH) or transient. A real-life retrospective trial aimed to determine predictive factors for PCH and verify its prevalence changes over time. It discovered the most important PCH predictors are the initial thyroid-stimulating hormone serum (TSH) and the blood spot TSH. Read More →

Homeostasis model assessment is negatively associated with the clamp-derived insulin sensitivity index in adolescents

Photo: a hand holding a glucose meter and pointing to a finger of the other hand. In the background, a glucose monitor.

The increase in the prevalence of type 2 diabetes and metabolic syndrome in children and adolescents is a health concern. Therefore, a valid and accessible method of assessing insulin resistance in this age group must be developed to monitor its progression and identifying adolescents at risk of developing associated factors. Read More →

Epidemiology and risk factors of hypoglycemia in type 1 diabetes in Brazil

Photo or composition. A cell phone and a blood glucose meter kit (two cylindrical objects, a round jar and the monitor with two buttons). Solid orange background.

Factors associated with hypoglycemia and severe hypoglycemia (SH) in individuals with type 1 diabetes mellitus (T1D) in Brazil shows that avoiding high doses of basal insulin and educating individuals about alcohol consumption and its consequence on glycemic control are simple measures that can contribute to reducing SH events. Read More →

Trabecular bone score and its evolving role in the assessment and management of clinical conditions

Photo: illustration of a spine in gray tones on a cardboard paper. Below a wooden board. In the background, illustrations on butcher paper in different sheets spread over a surface (hand bones, skull, foot bones).

Trabecular bone score (TBS) is a noninvasive measure of bone quality. A low TBS indicates degraded bone microarchitecture, predicts osteoporotic fracture, and is partially independent of clinical risk factors and bone mineral density. Today TBS has an evolving role in the assessment and management of several clinical conditions. Read More →

InsulinAPP application is effective and safe for the management of hyperglycemia on a hospitalist-managed ward

Imagem retangular na horizontal. Uma mão segurando um celular e a outra mão apontando para a tela. Na tela do celular um gradiente azul. No fundo círculos brancos e linhas tracejadas coloridas (azul, verde, amarelo, laranja, vermelho).

This retrospective study assessed metrics related to inpatient glycemic control using InsulinAPP, an application available for free in Brazil, on the hospitalist-managed ward of a local institution. The results indicated that the InsulinAPP using human insulin formulations was effective and safe for the management of hyperglycemia in this setting. Read More →

Sarcopenia prevalence did not increase in women undergoing gastric bypass despite weight loss

Graphic with number of patients with sarcopenia parameters in the bariatric and control groups (A) and in bariatric and control groups based on sarcopenia diagnosis (B)

Women (18-65 years old) who underwent bariatric surgery (BG) ≥ 2 years and reached stable weight ≥ 6 months, were investigated in an observational, cross-sectional study for sarcopenia’s presence. Patients subjected to Roux-en-Y gastric bypass did not show increased sarcopenia prevalence in comparison to non-operated women with obesity, despite the significant weight loss. Read More →

Impact of semioccluded vocal tract exercises and choral singing in congenital GH deficiency’s subjects

Photograph of a microphone on a dark background.

Isolated growth hormone deficiency (IGHD) individuals report normal general quality of life but rate their Voice-Related Quality of Life (V-RQOL) as low. Voice therapy with semioccluded vocal tract exercises and choral training can markedly improve V-RQOL scores, voice self-assessment and auditory-perceptual analysis in IGHD subjects, although GH replacement therapy is not widely accepted. Read More →

Brazilian Medical Societies propose a new obesity classification based on weight history

A yellow tape measure spirals over a wooden floor. Behind it the feet of a white-skinned person on top of a bathroom scale.

In the new obesity classification, individuals losing a specific proportion of weight are classified as having “reduced” or “controlled” obesity. This classification could help disseminate the concept of clinical benefits derived from modest weight loss, allowing subjects with obesity and their health care professionals to focus on strategies for weight maintenance instead of further weight reduction. Read More →

Canagliflozin seems to be more potent in reducing glycated hemoglobinand and body weight in patients with type 2 diabetes


Among the different doses of gliflozins commercially available in Brazil, Canagliflozin 300 mg had the greatest benefit in terms of body weight reduction, however, results were not different from empagliflozin 25 mg and dapagliflozin 10 mg. It’s not worthwhile to increase gliflozins doses with the intent to further decrease glycated hemoglobin or body weight. Read More →

The prognosis of differentiated thyroid cancer is not affected by pregnancy

A pregnant white woman in a white dress, a ring on the finger. Some bush in the background

Pregnancy had no impact on the natural course of differentiated thyroid cancer. Disease progression after pregnancy was limited and probably related to more aggressive disease and higher risk stratification at diagnosis. Still, mild disease progression may have occurred asymptomatically in some patients. Read More →