Tag: Archives Of Endocrinology And Metabolism

InsulinAPP application is effective and safe for the management of hyperglycemia on a hospitalist-managed ward

Imagem retangular na horizontal. Uma mão segurando um celular e a outra mão apontando para a tela. Na tela do celular um gradiente azul. No fundo círculos brancos e linhas tracejadas coloridas (azul, verde, amarelo, laranja, vermelho).

This retrospective study assessed metrics related to inpatient glycemic control using InsulinAPP, an application available for free in Brazil, on the hospitalist-managed ward of a local institution. The results indicated that the InsulinAPP using human insulin formulations was effective and safe for the management of hyperglycemia in this setting. Read More →

Sarcopenia prevalence did not increase in women undergoing gastric bypass despite weight loss

Graphic with number of patients with sarcopenia parameters in the bariatric and control groups (A) and in bariatric and control groups based on sarcopenia diagnosis (B)

Women (18-65 years old) who underwent bariatric surgery (BG) ≥ 2 years and reached stable weight ≥ 6 months, were investigated in an observational, cross-sectional study for sarcopenia’s presence. Patients subjected to Roux-en-Y gastric bypass did not show increased sarcopenia prevalence in comparison to non-operated women with obesity, despite the significant weight loss. Read More →

Impact of semioccluded vocal tract exercises and choral singing in congenital GH deficiency’s subjects

Photograph of a microphone on a dark background.

Isolated growth hormone deficiency (IGHD) individuals report normal general quality of life but rate their Voice-Related Quality of Life (V-RQOL) as low. Voice therapy with semioccluded vocal tract exercises and choral training can markedly improve V-RQOL scores, voice self-assessment and auditory-perceptual analysis in IGHD subjects, although GH replacement therapy is not widely accepted. Read More →

Brazilian Medical Societies propose a new obesity classification based on weight history

A yellow tape measure spirals over a wooden floor. Behind it the feet of a white-skinned person on top of a bathroom scale.

In the new obesity classification, individuals losing a specific proportion of weight are classified as having “reduced” or “controlled” obesity. This classification could help disseminate the concept of clinical benefits derived from modest weight loss, allowing subjects with obesity and their health care professionals to focus on strategies for weight maintenance instead of further weight reduction. Read More →

Canagliflozin seems to be more potent in reducing glycated hemoglobinand and body weight in patients with type 2 diabetes


Among the different doses of gliflozins commercially available in Brazil, Canagliflozin 300 mg had the greatest benefit in terms of body weight reduction, however, results were not different from empagliflozin 25 mg and dapagliflozin 10 mg. It’s not worthwhile to increase gliflozins doses with the intent to further decrease glycated hemoglobin or body weight. Read More →

The prognosis of differentiated thyroid cancer is not affected by pregnancy

A pregnant white woman in a white dress, a ring on the finger. Some bush in the background

Pregnancy had no impact on the natural course of differentiated thyroid cancer. Disease progression after pregnancy was limited and probably related to more aggressive disease and higher risk stratification at diagnosis. Still, mild disease progression may have occurred asymptomatically in some patients. Read More →

Multifocality and LN metastasis are independent risk factors for incomplete response in TMC patients

Man getting ultrasound of a thyroid from doctor in hospital

This was a retrospective study that aimed at identifying possible risk factors associated with an incomplete response to therapy in thyroid microcarcinoma (TMC) treated with total thyroidectomy, with or without radioactive iodine (RAI) therapy, reclassified according to the response to treatment into “favorable” (excellent/indeterminate) or “unfavorable” (biochemical/structural incomplete) responses. Read More →

Results from the ELSA-Brasil trial shows the incidence of thyroid diseases in the country

Results from ELSA-Brasil trial showed a high incidence of hypothyroidism, which is compatible with a country with a more-than-adequate iodine intake. The low women: men ratio of the incidence of thyroid dysfunction highlights the importance of the diagnosis of thyroid diseases among men in the country. Read More →

Isthmic nodules have similar US and cytopathological features and tumor characteristics to non-isthmic ones

Logo do periódico Archives of Endocrinology and Metabolism

Patients who underwent thyroidectomy were retrospectively reviewed. Group-1 (isthmic) and Group-2 (lober; non-isthmic) were compared. Isthmic nodules appear to be indolent because of having lower malignancy rate. The surgery with limited extent or follow-up might seem to be reliable in the management of patients having isthmic nodules especially with indeterminate cytology. Read More →

Study shows clinical value of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules

This trial showed that SNPs rs1800472 and rs1800469 were associated with characteristics of PTC aggressiveness. TGFB1 mRNA expression was upregulated in PTC and downregulated in benign samples. TGFBR1 mRNA expression was upregulated in goiter and PTC, but downregulated in FA. On the other hand, TGFBR2 was downregulated in all histological types analyzed. Read More →