A 20-year single-center study of 63 pediatric thyroid cancer patients reveals that children under 12 present more aggressive disease and higher recurrence rates. Despite similar family histories across ages, younger patients had more surgical complications and cervical metastases, emphasizing the need for age-specific care and long-term follow-up. … Read More →
Practical Approaches for Applying the Brazilian Dietary Guidelines in Clinical Practice
Seeking to integrate the Brazilian Dietary Guidelines into clinical practice, some strategies highlighting tools like protocols for dietary advice and meal plans are presented, aiming to improve healthcare professionals’ ability to promote healthy eating, reduce ultra-processed food consumption, and prevent chronic diseases, contributing to better public health outcomes in Brazil. … Read More →
After 115 years, a revisit to tropical diseases
More than 100 years on, diseases such as tuberculosis, malaria and vector control continue to be major challenges for developing countries, reflecting the continuing relevance of these tropical medicine topics to world science … Read More →
Extreme obesity is a challenging disease to manage and requires a multifactorial approach
Extreme obesity is a challenging disease that can present with multiple comorbidities and high rates of mortality and complications. Although lifestyle changes and anti-obesity drugs are recommended, they are less effective than bariatric surgery. … Read More →
Budget impact of adding cabergoline is lower than other treatments for Cushing’s disease In Brazil
The estimated budget impact of adding cabergoline to the formulary for Cushing’s disease (CD) treatment within the Brazilian Public Health System would be about BRL $6 million. While cost savings cannot be expected, the budget impact of adding cabergoline would be lower than that of adding other treatment options. … Read More →
Active surveillance is cheaper than immediate surgery in low-risk papillary thyroid microcarcinoma
When comparing long-term medical costs of active surveillance (AS), partial thyroidectomy, and total thyroidectomy in patients with low-risk papillary thyroid microcarcinoma that receives care covered by their Public Health System, researchers concluded that the AS approach was less costly than immediate surgery over a 30-year follow-up period. … Read More →
115 years of Memórias do Instituto Oswaldo Cruz, reflections on the current model and the future of scientific journals
Reflections on the current scenario of large publishers, the emergence of “money-hungry” publishers and qualified journals that do not charge for publication and that try to survive in the face of a scientific model that values metrics in a vicious cycle for researchers, institutions, journals and funding agencies alike. … Read More →
Pregnant women treated with continuous subcutaneous insulin infusion have better glycemic control
In a comparison of maternal-fetal outcomes among T1D patients treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injections during pregnancy, a higher frequency of cesarean and a lower occurrence of congenital malformations group were observed in the CSII. Adjusted results might indicate that these are influenced by glycemic control. … Read More →
Central fat accumulation in women with polycystic ovary syndrome evaluated by different methods
In women with polycystic ovary syndrome and normal body mass index, both dual-energy X-ray absorptiometry and the adiposity indices, visceral adiposity index and lipid accumulation product, are the most sensitive methods to evaluate total body fat and fat accumulation in the central abdominal region. … Read More →
Stratifying hypoechogenicity into 3 degrees improves ultrasound thyroid nodule risk stratification
The analysis of different degrees of hypoechogenicity in thyroid nodules shows that the classification into three grades (mild, moderate, and severe) allows for better differentiation between benign and malignant nodules. The method can avoid unnecessary invasive procedures, in addition to improving efficiency and accuracy in the evaluation of thyroid nodules. … Read More →
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