The estimated budget impact of adding cabergoline to the formulary for Cushing’s disease (CD) treatment within the Brazilian Public Health System would be about BRL $6 million. While cost savings cannot be expected, the budget impact of adding cabergoline would be lower than that of adding other treatment options. … Read More →
Active surveillance is cheaper than immediate surgery in low-risk papillary thyroid microcarcinoma
When comparing long-term medical costs of active surveillance (AS), partial thyroidectomy, and total thyroidectomy in patients with low-risk papillary thyroid microcarcinoma that receives care covered by their Public Health System, researchers concluded that the AS approach was less costly than immediate surgery over a 30-year follow-up period. … Read More →
115 years of Memórias do Instituto Oswaldo Cruz, reflections on the current model and the future of scientific journals
Reflections on the current scenario of large publishers, the emergence of “money-hungry” publishers and qualified journals that do not charge for publication and that try to survive in the face of a scientific model that values metrics in a vicious cycle for researchers, institutions, journals and funding agencies alike. … Read More →
Pregnant women treated with continuous subcutaneous insulin infusion have better glycemic control
In a comparison of maternal-fetal outcomes among T1D patients treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injections during pregnancy, a higher frequency of cesarean and a lower occurrence of congenital malformations group were observed in the CSII. Adjusted results might indicate that these are influenced by glycemic control. … Read More →
Central fat accumulation in women with polycystic ovary syndrome evaluated by different methods
In women with polycystic ovary syndrome and normal body mass index, both dual-energy X-ray absorptiometry and the adiposity indices, visceral adiposity index and lipid accumulation product, are the most sensitive methods to evaluate total body fat and fat accumulation in the central abdominal region. … Read More →
Stratifying hypoechogenicity into 3 degrees improves ultrasound thyroid nodule risk stratification
The analysis of different degrees of hypoechogenicity in thyroid nodules shows that the classification into three grades (mild, moderate, and severe) allows for better differentiation between benign and malignant nodules. The method can avoid unnecessary invasive procedures, in addition to improving efficiency and accuracy in the evaluation of thyroid nodules. … Read More →
Electrocardiogram in the Pre-Exercise Evaluation of Children and Adolescents
The electrocardiogram (ECG) has a crucial role in the early identification of risks, particularly in children and adolescents. Detection of cardiac alterations in 3.3% of asymptomatic participants, despite no personal or family history of heart disease, highlights the importance of ECG in ensuring the cardiac well-being of young individuals. … Read More →
Serum magnesium concentrations one day after total thyroidectomy are predictors for calcium replacement
The ability of serum magnesium (Mg) (measured on the first postoperative day; Mg1PO) to predict the need for calcium (Ca) replacement, was assessed in patients undergoing total thyroidectomy (TT). In this group of subjects, serum Mg1PO was identified as the isolated predictor for the need for Ca replacement. … Read More →
Predictive factors for permanent congenital hypothyroidism was shown by a real-life study in Brazil
Congenital hypothyroidism can be permanent (PCH) or transient. A real-life retrospective trial aimed to determine predictive factors for PCH and verify its prevalence changes over time. It discovered the most important PCH predictors are the initial thyroid-stimulating hormone serum (TSH) and the blood spot TSH. … Read More →
Homeostasis model assessment is negatively associated with the clamp-derived insulin sensitivity index in adolescents
The increase in the prevalence of type 2 diabetes and metabolic syndrome in children and adolescents is a health concern. Therefore, a valid and accessible method of assessing insulin resistance in this age group must be developed to monitor its progression and identifying adolescents at risk of developing associated factors. … Read More →
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