In search of new alternatives for the treatment of portal hypertension, a model validation in medium-sized animals was performed, allowing the improvement of techniques applied in cases of gastrointestinal hemorrhage and indicating the direction for advances in diagnostic and therapeutic procedures that aim to cure diseases and save lives. … Read More →
Brazilian Medical Societies propose a new obesity classification based on weight history
In the new obesity classification, individuals losing a specific proportion of weight are classified as having “reduced” or “controlled” obesity. This classification could help disseminate the concept of clinical benefits derived from modest weight loss, allowing subjects with obesity and their health care professionals to focus on strategies for weight maintenance instead of further weight reduction. … Read More →
Canagliflozin seems to be more potent in reducing glycated hemoglobinand and body weight in patients with type 2 diabetes
Among the different doses of gliflozins commercially available in Brazil, Canagliflozin 300 mg had the greatest benefit in terms of body weight reduction, however, results were not different from empagliflozin 25 mg and dapagliflozin 10 mg. It’s not worthwhile to increase gliflozins doses with the intent to further decrease glycated hemoglobin or body weight. … Read More →
COVID-19 Affects Perioperative Morbidity and Mortality in Patients Requiring Cardiovascular Surgery
A retrospective Brazilian multicenter cohort study with 104 patients investigated how COVID-19 affects the perioperative period of cardiovascular surgery. Patients with a positive RT-PCR test within ten days before or after surgery and those presenting with positive RT-PCR test > 10 days after surgery showed significantly higher postoperative complications and death. … Read More →
The prognosis of differentiated thyroid cancer is not affected by pregnancy
Pregnancy had no impact on the natural course of differentiated thyroid cancer. Disease progression after pregnancy was limited and probably related to more aggressive disease and higher risk stratification at diagnosis. Still, mild disease progression may have occurred asymptomatically in some patients. … Read More →
Multifocality and LN metastasis are independent risk factors for incomplete response in TMC patients
This was a retrospective study that aimed at identifying possible risk factors associated with an incomplete response to therapy in thyroid microcarcinoma (TMC) treated with total thyroidectomy, with or without radioactive iodine (RAI) therapy, reclassified according to the response to treatment into “favorable” (excellent/indeterminate) or “unfavorable” (biochemical/structural incomplete) responses. … Read More →
Results from the ELSA-Brasil trial shows the incidence of thyroid diseases in the country
Results from ELSA-Brasil trial showed a high incidence of hypothyroidism, which is compatible with a country with a more-than-adequate iodine intake. The low women: men ratio of the incidence of thyroid dysfunction highlights the importance of the diagnosis of thyroid diseases among men in the country. … Read More →
Isthmic nodules have similar US and cytopathological features and tumor characteristics to non-isthmic ones
Patients who underwent thyroidectomy were retrospectively reviewed. Group-1 (isthmic) and Group-2 (lober; non-isthmic) were compared. Isthmic nodules appear to be indolent because of having lower malignancy rate. The surgery with limited extent or follow-up might seem to be reliable in the management of patients having isthmic nodules especially with indeterminate cytology. … Read More →
Amyloidosis, a frequently missed diagnosis
Amyloidosis is a wide-spectrum disorder associated with chronic illnesses, plasma cell diseases, and chronic hemodialysis. The clinical presentation in many cases challenges the least warned health care provider. The study shows a detailed multivisceral involvement by the amyloid deposition. … Read More →
Study shows clinical value of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules
This trial showed that SNPs rs1800472 and rs1800469 were associated with characteristics of PTC aggressiveness. TGFB1 mRNA expression was upregulated in PTC and downregulated in benign samples. TGFBR1 mRNA expression was upregulated in goiter and PTC, but downregulated in FA. On the other hand, TGFBR2 was downregulated in all histological types analyzed. … Read More →
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