Monthly Archives: June 2022

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Sequencing of the first case of the monkeypox virus in Brazil

Genome sequencing of the B.1 lineage

Monkeypox virus, a zoonotic virus endemic to the African continent, has been reported in 33 non-endemic countries since May 2022. We report an almost complete genome of the first confirmed case of MPXV in Brazil. Shotgun metagenomic sequencing was completed in 18 hours, from DNA extraction to consensus sequence generation. Read More →

Impact of semioccluded vocal tract exercises and choral singing in congenital GH deficiency’s subjects

Photograph of a microphone on a dark background.

Isolated growth hormone deficiency (IGHD) individuals report normal general quality of life but rate their Voice-Related Quality of Life (V-RQOL) as low. Voice therapy with semioccluded vocal tract exercises and choral training can markedly improve V-RQOL scores, voice self-assessment and auditory-perceptual analysis in IGHD subjects, although GH replacement therapy is not widely accepted. Read More →

Genomic monitoring of Holstein cattle as a strategy in dairy production

Photograph of a cow

Dairy production is one of the most important sectors of the Uruguayan economy. The genetic disorders of the “Holstein” breed cause production problems, compromising the sustainability of the milk production. The genomic monitoring of carrier animals is necessary to avoid the spread of lethal and semi-lethal alleles and to reduce the economic losses to dairy farming. Read More →

CEVAP: ready for the 21st century

CEVAP has been working diligently since its founding in translational research with animal venoms. During this 30-year journey, a scientific journal was launched, two biopharmaceuticals were developed and numerous professionals, academic or not, were trained. Now, CEVAP is heading towards its future looking towards the creation of a factory aiming at scientific research. Read More →

Memorial text in honor of Dr. Ángela Restrepo Moreno

An example of competence, researchers education, ability to work in group, and also love to her profession, her team and her country, Dr. Ángela Restrepo Moreno will be forever missed. The present text aims honor the memory and accomplishments of this extraordinary researcher, whose contribution to science is immortalized. Read More →

Time use and food insecurity in female-headed households in Brazil

Food insecurity is mostly observed in female headed households in Brazil. Based on the assumptions of the feminization of poverty and in light of Feminist Economics theory, it is observed that households headed by women tend to be in a greater situation of vulnerability, although they allocate food resources better. Read More →

Research Group on Paracoccidioidomycosis of Botucatu Medical School

The Research Group on Paracoccidioidomycosis of Botucatu Medical School united researchers with different specialties from UNESP and later on from other institutions in Brazil and from other countries. The activities of the group brought lessons such as updating the new languages of the biological knowledge and the integration of specialists from different fields. Read More →

Bioprospecting animal toxins as powerful ligands for ion channels and G-protein coupled receptors as therapeutic targets

The Laboratory of Toxicology and Pharmacology holds the expertise to perform experiments involving the interaction of toxins with different ion channels and G-protein coupled receptors. The purification and identification of novel compounds can also be carried out, which makes the research center a reference worldwide in the Toxinology field and state-of-the-art target-based drug discovery. Read More →

Biopharmaceutical products born in a Brazilian public university

Since 2010, two biological products have been developed by the CEVAP/UNESP, the fibrin sealant and the apilic antivenom. In 2022, UNESP has begun the construction of a Factory for the Production of Pilot Batches for Clinical Research. This pioneering initiative will contribute to the establishment of biopharma innovation ecosystems and creation of wealth in the country. Read More →

Isolation and characterization of new compounds derived from animal poisons and venoms: challenges and perspectives

The Laboratory of Animal Toxins is equipped to perform the isolation, biochemical, structural and functional characterization of toxins from animal venoms, as well as the heterologous expression of molecules with potential biotechnological application. PEGylation of peptides and proteins is also carried out to increase their potential use as a drug. Read More →