Results from ELSA-Brasil trial showed a high incidence of hypothyroidism, which is compatible with a country with a more-than-adequate iodine intake. The low women: men ratio of the incidence of thyroid dysfunction highlights the importance of the diagnosis of thyroid diseases among men in the country. … Read More →
Isthmic nodules have similar US and cytopathological features and tumor characteristics to non-isthmic ones
Patients who underwent thyroidectomy were retrospectively reviewed. Group-1 (isthmic) and Group-2 (lober; non-isthmic) were compared. Isthmic nodules appear to be indolent because of having lower malignancy rate. The surgery with limited extent or follow-up might seem to be reliable in the management of patients having isthmic nodules especially with indeterminate cytology. … Read More →
Amyloidosis, a frequently missed diagnosis
Amyloidosis is a wide-spectrum disorder associated with chronic illnesses, plasma cell diseases, and chronic hemodialysis. The clinical presentation in many cases challenges the least warned health care provider. The study shows a detailed multivisceral involvement by the amyloid deposition. … Read More →
Study shows clinical value of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules
This trial showed that SNPs rs1800472 and rs1800469 were associated with characteristics of PTC aggressiveness. TGFB1 mRNA expression was upregulated in PTC and downregulated in benign samples. TGFBR1 mRNA expression was upregulated in goiter and PTC, but downregulated in FA. On the other hand, TGFBR2 was downregulated in all histological types analyzed. … Read More →
Serum calcitonin levels shows more sensitivity than cytopathology for the medullary thyroid cancer diagnosis
In the present study, serum calcitonin levels were more sensitive than cytopathology for diagnosis of medullary thyroid cancer (MTC) and were able to identify all patients who could not be diagnosed by FNAB. Besides, Bethesda category III was more prevalent in the group of patients carrying this neoplasm. … Read More →
What causes a longer stay in the hospital for elderly with epilepsy?
Epilepsy in the elderly is quite prevalent and can bring serious complications to hospitalized patients. But what factors can predict which of these patients will remain in the hospital for a longer time and thus increase mortality and hospitalization costs? … Read More →
Development of a new alternative to aggressive spinal surgery for the treatment of severe deformities
Modern spine surgery was born in 1983 with Cotrel-Dubousset instrumentation, making it possible to perform complex spinal surgery. The Dubousset team recently developed the “Bipolar Concept”, a simpler, less aggressive, and effective method for the treatment of severe spinal deformities, which can be used even in less equipped places.Modern spine surgery was born in 1983 with Cotrel-Dubousset instrumentation, making it possible to perform complex spinal surgery. The Dubousset team recently developed the “Bipolar Concept”, a simpler, less aggressive, and effective method for the treatment of severe spinal deformities, which can be used even in less equipped places. … Read More →
Researchers validate a questionnaire in Portuguese to detect a common sleep disorder
Patients with Parkinson’s disease commonly present with a sleep disorder characterized by moving arms and legs violently while dreaming. The diagnosis is only made by an expensive exam called Polysomnography. Researchers validated the Brazilian Portuguese version of a screening questionnaire to help detect this disorder. … Read More →
The inclusion of BRAFV600E mutational status has a limited impact on risk stratification in papillary thyroid carcinoma
Although the prognostic role of BRAFV600E mutation in papillary thyroid carcinoma (PTC) is controversial, the American Thyroid Association (ATA) includes the mutational status in their risk stratification system. The present study aimed to evaluate the impact of the BRAFV600E mutation status on risk stratification as well as on disease outcomes in patients with PTC. … Read More →
The man and the physician who greatly contributed to the Pathology teaching in Brazil
The first Brazilian Medical School dates from the beginning of the 19th century influenced by the explosion of the arts and science knowledge of the 19th century. Following this brilliant era, the Brazilian journey of Dr. Luigi Bogliolo ensues, the man and Doctor who struggled for improving the medical teaching, prioritizing the clinical and pathological correlation. … Read More →
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